Summary: This report is based on seven papers for the Global Burden of Disease Study 2010 published in The Lancet (December 13, 2010; 380). This publication summarizes the global GBD 2010 findings as well as the regional findings for East Asia and Pacific (EAP). It also explores intraregional differences in diseases, injuries, and risk factors. Main findings for East Asia and Pacific include the following: 1) The EAP region has made dramatic progress in reducing mortality and prolonging life since 1970; 2) over the last 20 years, the region has succeeded in decreasing premature death and disability from most communicable, newborn, nutritional, and maternal<BR>causes, but HIV/AIDS remains a persistent challenge; 3) despite improvements, substantial burdens of communicable, newborn, nutritional, and maternal causes persisted in low- and lower-middle-income countries in East Asia and Pacific such as Cambodia, Indonesia, Laos, Myanmar, Papua New Guinea, Timor-Leste, and Vanuatu; 4) China is the most epidemiologically advanced country in the region; 5) Between 1990 and 2010, demographic changes contributed to rising disease burden from many non-communicable causes, especially from stroke, mental disorders such as major depressive disorders and anxiety, musculoskeletal disorders including low back pain and neck pain, diabetes, and trachea, bronchus,<BR>and lung cancers; 6) As countries in EAP have become more developed, road injuries have taken a growing toll on human health; 7) Low back pain, neck pain, and other musculoskeletal disorders, as well as mental disorders such as depression, were dominant causes of disability; and 8) Risk factors such as dietary risks, high blood pressure, smoking, household and ambient particulate matter air pollution, high fasting plasma glucose, alcohol use, and high BMI were leading risk factors for premature death and disability.
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