Human Development and Public Services

About

Countries

Data & Research

Learning

News

Projects & Operations

Publications

Topics

Home > Data & Research > Research > Programs > Human Development an... > ImagebankContents

The epidemiological impact of an HIV vaccine on the HIV/AIDS epidemic in Southern India, Volume 1

Author:	Nagelkerke, Nico J.D.; De Vlas, Sake J.;	Collection Title:	Policy, Research working paper ; no. WPS 2978
Country:	India;	Date Stored:	2003/03/22
Document Date:	2003/02/28	Document Type:	Policy Research Working Paper
Language:	English	Region:	South Asia
Report Number:	WPS2978	Sub Sectors:	Health
SubTopics:	HIV AIDS and Business; Poverty and Health; Disease Control & Prevention; Health Monitoring & Evaluation; Health Service Management and Delivery; Adolescent Health; Public Health Promotion; HIV AIDS	Volume No:	1

Summary: The potential epidemiological impact of preventive HIV vaccines on the HIV epidemic in Southern India is examined using a mathematical deterministic dynamic compartmental model. Various assumptions about the degree of protection offered by such a vaccine, the extent of immunological response of those vaccinated, and the duration of protection afforded are explored. Alternative targeting strategies for HIV vaccination are simulated and compared with the impact of conventional prevention interventions in high-risk groups and the general population. The impact of disinhibition (increased risk behavior due to the presence of a vaccine) is also considered. Vaccines that convey a high degree of protection in a share of or all of those immunized and that convey life-long immunity are the most effective in curbing the HIV epidemic. Vaccines that convey less than complete protection may also have substantial public health impact, but disinhibition can easily undo their effects and they should be used combined with conventional prevention efforts. Conventional interventions that target commercial sex workers and their clients to increase condom use can also be highly effective and can be implemented immediately, before the arrival of vaccines.


Official Documents Official, scanned versions of documents (may include signatures, etc.)
File Type		Description	File Size (mb)

	PDF 36 pages	Official version*	2.52 (approx.)
	Text	Text version**


Light-Weight Documents Lighter (less MB) documents which may or may not be the final, official version
File Type		Description	File Size (mb)

	PDF 30 pages	WPS2978	0.23

* The official version is derived from scanning the final, paper copy of the document and is the official,
archived version including all signatures, charts, etc.

** The text version is the OCR text of the final scanned version and is not an accurate representation of the final text.
It is provided solely to benefit users with slow connectivity.

Permanent URL for this page: http://go.worldbank.org/RRHQD07AJ0